Spiders can be a nuisance when they invade our homes, but fear not, as there are numerous spider killer sprays on the market to help you keep these eight-legged creatures at bay. In this article, we will review 10 of the best spider killer sprays for indoor use that you can find on Amazon. These sprays have been carefully selected based on their effectiveness, ease of use, and customer reviews. If you’re in search of a reliable spider killer spray, keep on reading to find the perfect solution for your needs.

1. Terro Spider Killer Spray

Terro Spider Killer Spray tops our list with its powerful formula that effectively eliminates spiders and other crawling insects on contact. This indoor spray not only kills spiders but also keeps them away for a long time, thanks to its residual action. It is safe to use around pets and children when used as directed, and its non-staining formula ensures that your furniture and fabrics remain untouched.

2. Ortho Home Defense Insect Killer

If you’re looking for a multi-purpose spider killer spray, the Ortho Home Defense Insect Killer is an excellent choice. This spray not only kills spiders but also combats various other pests like ants, roaches, and fleas. Its fast-acting formula provides long-lasting protection, creating a barrier that keeps spiders from entering your home. It is also odor-free and safe to use on different surfaces.

3. Wet & Forget Miss Muffet’s Revenge Spider Killer

Wet & Forget Miss Muffet’s Revenge Spider Killer offers a unique and convenient solution for spider infestations. This spray features a long-range nozzle, allowing you to reach spiders in difficult-to-access areas, such as corners and ceilings. Its water-based formula dries clear, leaving no odor or residue. One application of this spider killer spray provides up to 12 months of protection.

4. Raid Max Spider & Scorpion Killer

Raid Max Spider & Scorpion Killer is a highly effective spray that targets not only spiders but also scorpions. Its specialized formula kills spiders instantly upon contact and provides residual protection, preventing future infestations. This spray is suitable for indoor use, but caution should be exercised around children and pets. It is recommended to keep the treated area well-ventilated during application.

5. Black Flag Spider & Scorpion Killer

Another powerful spider killer spray is the Black Flag Spider & Scorpion Killer. It not only eliminates spiders but also targets scorpions, ants, and other crawling insects. This indoor spray features a quick-kill formula that provides immediate results, making it ideal for those who want to get rid of spiders fast. It is a non-staining formula that can be used confidently around your home.

6. Hot Shot Spider & Scorpion Killer

For those seeking a spider killer spray that offers long-lasting protection, the Hot Shot Spider & Scorpion Killer is an excellent option. This spray kills spiders, scorpions, and other pests on contact while also preventing their return for up to 16 weeks. Its non-staining formula makes it safe to use on various surfaces, and it is odor-free for your convenience.

7. Eco Defense Organic Spider Repellent

If you prefer an organic and environmentally friendly option, Eco Defense Organic Spider Repellent is an ideal choice. This spray is formulated using natural ingredients like essential oils, which are effective in repelling spiders and other crawling insects. It is safe to use indoors and around children and pets, giving you peace of mind while keeping spiders at bay.

8. Mighty Mint Peppermint Oil Spider Repellent

Mighty Mint Peppermint Oil Spider Repellent is another natural option that effectively repels spiders. This spray uses peppermint oil as its active ingredient, creating a scent that spiders find unpleasant and avoid. It is safe to use in any indoor area and has a refreshing peppermint aroma, making it a pleasant alternative to chemical-based spider killer sprays.

9. Rockwell Labs Cy-Kick CS

For professional-strength spider eradication, Rockwell Labs Cy-Kick CS is a top contender. This concentrated suspension is designed to be mixed with water and applied using a sprayer. It eliminates spiders and provides residual protection for up to 90 days. Although this spray requires more effort for application, it offers powerful and long-lasting results that make it worth considering.

10. Tempo Ultra SC Contact Insecticide

Tempo Ultra SC Contact Insecticide is a broad-spectrum solution that eliminates spiders, as well as other insects like ants and beetles. This concentrated formula can be mixed with water and applied both indoors and outdoors. It provides a quick knockdown effect, killing spiders upon contact, and continues to offer protection for several weeks.


When it comes to eliminating spiders from your home, these 10 spider killer sprays offer effective solutions to help you regain control. Whether you prefer a ready-to-use spray, an organic option, or a professional-strength solution, there is a spider killer spray on this list for everyone. Remember to always read and follow the instructions provided by the manufacturer to ensure safe and effective use. Say goodbye to unwanted spiders and enjoy a spider-free living space by choosing the spider killer spray that suits your needs and preferences.

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